The neuropeptide substance P regulates aldosterone secretion in human adrenals

History of a Pioneering Neuropeptide: Substance P

1 Extraction, Biological Testing and Structural Elucidation . . . . . . . . . . . . 1 2 Masanori Otsuka and the Action of Substance P in the Spinal Cord . . . . . . 8 3 Radioimmunoassay and Immunohistochemistry of Substance P . . . . . . . . 8 4 Nicolas Jancs and Capsaicin . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 5 Peptide and Nonpeptide Transmitters in Primary Afferent Neuron...

Neuropeptide substance P induces mRNA expression and secretion of CXCL8 chemokine, and HDC in human umbilical cord blood mast cells.

PURPOSE Mast cells play an important role in innate and acquired immunity and are thought to be the cellular origin of most proteases and cytokines. Substance P (SP) and its receptor, NK-1R, play critical roles in immune regulation in human and animal models of inflammation. METHODS We used mature human cord blood mast cells (HCBMC) differentiated from cord blood CD34+ precursor activated wit...

Modulation of lymphatic muscle contractility by the neuropeptide substance P.

Substance P (SP) is a neuropeptide associated with sensory innervation of lymphoid tissue and a suspected modulator of lymphatic function in inflammation. Only a few studies have examined the effects of SP on lymphatic contraction, and it is not clear to what extent SP acts directly on the lymphatic muscle and/or endothelium or indirectly through changes in intraluminal filling pressure seconda...

Expression in Inflammation Substance P Regulates Somatostatin

Effects of a Skin Neuropeptide (Substance P) on Cutaneous Microflora

BACKGROUND Skin is the largest human neuroendocrine organ and hosts the second most numerous microbial population but the interaction of skin neuropeptides with the microflora has never been investigated. We studied the effect of Substance P (SP), a peptide released by nerve endings in the skin on bacterial virulence. METHODOLOGY/PRINCIPAL FINDINGS Bacillus cereus, a member of the skin transi...